Rebecca Paul

The use of puberty blockers on healthy children is deeply wrong. Children given those drugs are being locked into their discomfort and put on a one-way pathway to cross-sex hormones and surgeries. All of that leads to a lifetime of sexual impairment, fertility issues, bone density loss and other catastrophic psychological and emotional impacts. No child put on puberty blockers at the earliest stage of puberty and whose natural puberty is blocked will ever have an orgasm or be fertile. That is what anyone in this room cheerleading this trial is supporting. In December, the Health Secretary said at the Dispatch Box: “Am I comfortable that this clinical trial has undergone the proper process and ethical approval to ensure the highest standards and supervision? Yes, I am comfortable about that.”—[Official Report, 17 December 2025; Vol. 777, c. 929.] However, on 20 February, we found out that the MHRA had U-turned and was expressing serious concerns about the current trial. The issues it raised were not new, though, having been raised from the outset by many in this room. Making children infertile and harming bone structure are not minor points of detail, but fundamental safety flaws. That last-minute intervention raises questions about the rigour and diligence of the overall approval process. How did a trial with such potentially catastrophic health impacts make it through the research ethics committee approval process? Having looked through the minutes of the meetings, I can see that the committee members met three times over Zoom; nine out of 12 attended the first, only five attended the second and only three attended the third. What stands out most to me is the REC’s delegation to a sub-committee of approval responsibilities for such a profoundly dangerous trial. Section 4.2.24 of the REC governance policy document indicates that sub-committees can be used when “research proposals…present no material ethical issues”. I am therefore staggered that it took the decision to delegate approval responsibilities in this case.